Second, the analysis of angptl4 mRNA expression in the main types of VHL disease-associated tumors (ie, ccRCC, pancreatic endocrine and serous tumors, pheochromocytoma, and hemangioblastoma) revealed that angptl4 mRNA expression is restricted to ccRCCs (100% of cases) and hemangioblastomas (97.6% of cases), independently of the VHL status of these tumors. This evidence concerns the gene VHL and hereditary pheochromocytoma-paraganglioma.