The angptl4 mRNA expression was also limited to ccRCC subtype in local recurrence and metastatic cases of RCC (ie, 86.7% [26 of 30] positive in secondary ccRCCs, and 0% [0 of 7] positive in non-ccRCC secondary renal tumors). This evidence concerns the gene ANGPTL4 and nonpapillary renal cell carcinoma.