UMOD and cancer: We also analyzed the ten most influential genes that caused the reduction in specialization in all eleven tissues of dataset A. For each tissue, we found examples of organ-specific genes that were switched off in the corresponding cancer tissue, including Chondroadherin (CHAD) in bone, Uromodulin (UMOD) in kidney, the acid phosphatase prostate specific (ACPP) gene in the prostate, and a gene for the spermatogenesis-associated protein in the testis (Table S12).