Witze et al[14] showed that acute response of melanoma cell lines to Wnt5A involves recruitment of major cytoskeletal proteins (actin and myoxin IIB) and Frizzled 3 and melanoma cell adhesion molecule into an intracellular structure via Wnt5A regulation of Rab4 and RhoB guanosine triphosphatases. Here, RHOB is linked to melanoma.