Protein expression of Wnt5A in human prostate cancer and mechanisms of Wnt signaling in normal and cancer prostate cell lines, described here, provide the first framework within which the exact participation of Wnt receptors and secretory frizzled related proteins [20], [21] and various actin binding proteins and intermediary signaling molecules such as Ena/VASP and ERK1 [34], [38], could be investigated in cancer. Here, MAPK3 is linked to Familial prostate cancer.