In both primary culture (CD34+ umbilical cord blood and bone marrow cells) and erythroid-like cell lines (TF-1 and U-7 cells) RPS19 silencing mimics the DBA phenotype: impaired erythroid differentiation and proliferation of erythroid progenitors, cell growth arrest at G0/G1, and apoptosis [13, 15]. This evidence concerns the gene CD34 and Diamond-Blackfan anemia.