TP53 and Diamond-Blackfan anemia: Interestingly, the activation of p53 has been observed also when the expression of other ribosomal proteins not directly involved in the pathogenesis of DBA, like RPS8, RPS11, RPS18, and RPS6, is lost [23, 32], or when the expression of other factors involved in ribosome biogenesis like Bop1 [33], bap28 [34], or TCOF is impaired [35].