During an ongoing T. cruzi infection, a significant increase in the seric levels of BAFF was detected at 11 days p.i. BAFF concentration presented the highest value at the peak of parasitemia (day 11–15 p.i, [2]) and persisted elevated until the last day analyzed (day 32 p.i) (Fig 1A). Here, TNFSF13B is linked to parasitic infectious disease.