We obtained within tumor-reactive T cells averages of 25% IFNγ+ tetramer+ CD8 T cells upon specific restimulation compared to 5% under control conditions (p = 0.007), and 50% CD107+ tetramer+ CD8 T cells upon specific restimulation compared to 24% under control conditions (p = 0.02) (data not shown). The gene discussed is IFNG; the disease is neoplasm.