Among the genes with CGIs, there are some known tumor suppressors, such as P16/MTS1, DDC, PGRMC1, CAVEOLIN1 and some disease susceptibility genes such as DISC1 (disrupted in Schizophrenia 1) [43], TBX5 (Congenital heart failure or Holt-Oram syndrome) [44] (Table 1). Here, PGRMC1 is linked to Holt-Oram syndrome.