However, none of the three STAT4 SNPs with epistasis to the IL23R SNP rs11209026 were independently associated with CD, although there was a trend for association of CD with rs10174238 (rs10174238: p = 0.057; rs8179673: p = 0.12; rs7582694: p = 0.15; Table 4). Here, IL23R is linked to Cowden disease.