BECN1 and breast cancer: This effect was observed in multiple cell lines including U2OS (Fig. 1A–B), HEK293 (Fig. 1A & C), a colon cancer cell line HCT116 (Fig. 1D) and a breast cancer cell line MCF7 (Fig. 1E), suggesting that regulation of Beclin 1 by 14-3-3τ is general rather than cell line specific.