This increased pancreatic cancer predisposition was not limited to invasive tumors; the number of PanINs observed in 6-week-old Pdx1-Cre, KrasG12D/+, Lkb1flox/+ (KLC) mice was significantly increased when compared with Pdx1-Cre, KrasG12D/+ (KC) mice (Figure 1B, P = .007). This evidence concerns the gene PDX1 and pancreatic neoplasm.