Mutations in the LKB/STK11 tumor suppressor gene result in the Peutz–Jeghers syndrome,5,6 an autosomal-dominant condition characterized by hamartomatous polyps of the gastrointestinal tract and a dramatically increased risk of epithelial malignancies at other sites, including a >100-fold increased risk of pancreatic cancer.7-9 Restoration of silenced LKB1 in human pancreatic carcinoma cells induces apoptosis in vitro.10 This evidence concerns the gene STK11 and exocrine pancreatic carcinoma.