PDX1 and keratoconus: Lkb1 was detected in the nucleus and cytoplasm of normal duct cells and Pdx1-Cre, KrasG12D/+ (KC) PanIN lesions and tumors as expected (Figure 3A),28 but also in lesions and tumors from Pdx1-Cre, KrasG12D/+, Lkb1flox/+ (KLC) mice (Figure 3B), indicating maintenance of the wild-type allele.