PDX1 and pancreatic neoplasm: We found that Pdx1-Cre Lkb1flox/flox (LLC) mice develop pancreatic tumors with an incidence of 100% and a median survival of 68 days, while Pdx1-Cre, Lkb1flox/+ (LC) mice remained disease-free for 500 days (Figure 2A).Pdx1-Cre Lkb1flox/flox (LLC) mice presented with abdominal distention, and tumors arising in these mice were mucinous cystadenomas characterized by the presence of multiple large cysts, in some cases at the expense of most of the normal pancreas tissue (Figure 2B–E).