Ovulation has been suggested to cause genotoxic damage in the ovarian surface epithelium where ovarian cancers have traditionally been thought to originate; the recent findings of colocalization of γ-H2AX with p53 staining in STILs and STICs in the fimbria, adjacent to the ovarian surface, is therefore highly intriguing and will be important to explore further. The gene discussed is TP53; the disease is ovarian cancer.