CDKN2A and cancer: In support of this notion, mice carryingan extra copy of the p53 or Arf/Ink4 loci display increasedprotection against cancer without any change in aging [43], and micecarrying an additional copy of both these loci displayed delayed aging,correlating with decreased aging-related DNA-damage [51], suggestingthat Myc/Cdk2 inhibition not necessarily would have a negative impact on tissueregeneration and longevity.