A low dose of 1.2 mg of rFVIIa administrated to a study population with traumatic brain injury, warfarin use, and cirrhosis led to a reduction in the mean prothrombin time from 17.0 ± 3.2 s to 10.6 ± 1.4 s (p < 0.0001) [5] indicating an important increase in thrombin formation easily detected with this basic clotting test. Here, F2 is linked to injury.