Of note, this subject had a very low cytokine response during endotoxemia (TNF-α level of 169 pg/ml compared with the group mean of 814 ± 133 pg/ml, and IL-6 level of 508 pg/ml compared with the group mean of 1,111 ± 142 pg/ml) and an average cortisol response (0.29 to 0.67 μmol/l). This evidence concerns the gene TNF and serum lipopolysaccharide activity.