Similarly, stratifying separately by the presence of HLA-DRB1 SE and anti-CCP antibodies, the AA and AG genotypes of rs1801275 were associated with rheumatoid nodules (ORadj = 8.12 (95% CI, 1.59 to 41.44), P = 0.01; and ORadj = 2.96 (95% CI, 1.15 to 7.62), P = 0.02; respectively) in the multivariable model (data not shown). This evidence concerns the gene HLA-DRB1 and rheumatoid arthritis.