HLA-DRB1 and rheumatoid arthritis: After stratification for the presence of HLA-DRB1 SE and autoantibody status (RF or anti-CCP) in multivariable models, the rs1801275 AA genotype (ORadj = 8.08 (95% CI, 1.60 to 40.89); P = 0.01] and AG genotype (ORadj = 2.97 (95% CI, 1.08 to 8.17), P = 0.04)] were found to be associated with rheumatoid nodules (Table 2).