Likewise, stratifying separately by the presence of HLA-DRB1 SE and RF, the rs1801275 AA and AG genotypes (ORadj = 8.45 (95% CI, 1.57 to 45.44), P = 0.01; and ORadj = 3.57 (95% CI, 1.18 to 10.76), P = 0.02, respectively] and the rs1805010 AA genotype (ORadj = 4.52 (95% CI, 1.20 to 17.03), P = 0.03) were associated with rheumatoid nodules (data not shown). This evidence concerns the gene HLA-DRB1 and rheumatoid arthritis.