Using this approach we identified elevated expression of five genes located at the 12q24.31 amplicon; DIABLO, ZCCHC8, RSRC2, KNTC1 and MPHOSPH9. Among these five genes, DIABLO showed substantially elevated expression levels in a subset of the neuroblastoma samples, suggesting that it may have an oncogenic role in these tumors. The gene discussed is DIABLO; the disease is neuroblastoma.