Other examples are: 1) the release of pro-inflammatory bradykinin peptide by the parasite proteases during infection and consequent DC maturation induced by bradykinin B2 receptors (B2R) [41] and 2) the recently described DC maturation induced by NFATc1 activation and consequent IFN-γ production in a TLR-independent pathway [37]. This evidence concerns the gene IFNG and infection.