MYD88 and infection: Interestingly, Myd88−/−Trif−/− and Myd88−/−Ifnar−/− double knock out mice were even more sensitive to in vivo infection with T. cruzi than Myd88−/− mice, indicating that in addition to MyD88-dependent induction of proinflammatory cytokines, the TRIF-dependent production of type I IFN also contributes resistance to T. cruzi infection [8].