APOA1 and cardiovascular disorder: Given our findings, it is plausible that the association of SCARB1 SNPs with cardiovascular disease in their study could be mediated through the inflammatory effects of SCARB1. The second locus associated with Lp-PLA2 activity in our study is in the ZNF259/BUD13 region, which includes the apolipoprotein genes APOA5, APOA4, APOC3, and APOA1. This locus has been implicated in the control of serum triglyceride levels and increased coronary artery disease risk in a genome-wide association study [36].