Therefore, overexpression of Cyclin-D1 has been linked to the development and progression of cancer.[77, 78] So far, only one study has focused on the expression of Cyclin-D1 in the DSS-AOM model and the expression profile was assessed in integrin-linked kinase knockout mice and not compared to normal mucosa.[79] Our study describes for the first time a strong increase in the expression of Cyclin-D1 in adenomas compared to normal tissue in the DSS-AOM model of carcinogenesis – supporting the importance of the Cyclin-D1 and the Wnt pathway in this experimental setting. Here, CCND1 is linked to infectious otitis media.