IRS for Cyclin-D1 in adenomas compared to normal mucosa was 3.7 (± 0.1) vs. 1.4 (± 0.2) in the control group (H2O) compared to 3.7 (± 0.1) vs. 1.9 (± 0.1) in the TRD group (P ≤ 0.001) [Figure 3b]. The gene discussed is CCND1; the disease is treatment resistant depression.