Only in the TRD group, IRS for E-cadherin was significantly increased in adenoma (1.2 ± 0.2) compared to normal mucosa (0.3 ± 0.1) (P ≤ 0.001) whereas IRS in the control group (H2O) did not differ significantly between adenoma (0.8 ± 0.1) and normal mucosa (0.5 ± 0.2) [Figure 3d]. This evidence concerns the gene CDH1 and adenoma.