IRS for SOX9 in adenomas compared to normal mucosa was 1.9 (± 0.1) vs. 0.7 (± 0.1) in the control group (H2O) (P ≤ 0.01) compared to 2.0 (± 0.1) vs. 0.8 (± 0.1) in the TRD group (P ≤ 0.001) [Figure 3c]. Here, SOX9 is linked to treatment resistant depression.