TNFSF10 and familial pancreatic carcinoma: The combination indexes for LBH589 (e.g., 12.5 nM) and TRAIL (3.125–26 ng/ml) combination in the tested cell lines were <0.5 (Fig. 1C), indicating that LBH589 and TRAIL combination exerts synergistic effects on decreasing cell survival of pancreatic cancer cells.