When combined with LBH589, enhanced cell-killing effects were observed not only in TRAIL-sensitive cells (e.g., Bcpc-3), but also in TRAIL-resistant cell lines (e.g., Panc-1 and Capan-2) because the combination of LBH589 and TRAIL were much more than either agent alone in decreasing the survival of the pancreatic cancer cells (Fig. 1B). This evidence concerns the gene TNFSF10 and familial pancreatic carcinoma.