Thus, the modulation of these proteins is unlikely to be associated with LBH589-mediated potentiation of TRAIL-induced apoptosis in these cell lines; rather, increase in Bcl-2 and Mcl-1 may counteract LBH589's effect in sensitizing pancreatic cancer cells to TRAIL-induced apoptosis. The gene discussed is BCL2; the disease is familial pancreatic carcinoma.