TNFSF10 and pancreatic neoplasm: When combined with LBH589, enhanced cell-killing effects were observed not only in TRAIL-sensitive cells (e.g., Bcpc-3), but also in TRAIL-resistant cell lines (e.g., Panc-1 and Capan-2) because the combination of LBH589 and TRAIL were much more than either agent alone in decreasing the survival of the pancreatic cancer cells (Fig. 1B).