To determine the involvement of c-FLIP and survivin downregulation in sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by LBH589, we established Panc-1 cell lines that stably expressed ectopic FLPL or survivin through a lentivial expression system and then examined their responses to the combination of LBH589 and TRAIL. The gene discussed is TNFSF10; the disease is familial pancreatic carcinoma.