Moreover, numerous FHL2-interacting proteins including AR, AP1, PLZF, SKI, WT1, β-catenin, BRCA1 and E7 of human papillomavirus 16 [29], [30] have primary roles in various human cancers, implying that FHL2 may participate in transformation process through effects on the oncogenic activity of its partners. The gene discussed is FHL2; the disease is cancer.