The most common of the hereditary syndromes are germline mutations in the von Hippel–Lindau (VHL) tumour-suppressor gene on chromosome 3p, which is associated exclusively with the clear cell histological subtype (Czene and Hemminki, 2002; Hung et al, 2007; Chow and Devesa, 2008). This evidence concerns the gene VHL and neoplasm.