Interestingly, it has been previously demonstrated that key secreted inflammatory factors, such as Aif1(allograft inflammatory factor-1) (upregulated nearly 3-fold in Cav-1 (-/-)stromal cells; Supplementary Tables) promote NFkB-activation, the paracrinegrowth of ER-negative breast cancer cells [29], and are involved in thepathogenesis of pro-fibrotic diseases, such as scleroderma (systemic sclerosis)[30-32]. This evidence concerns the gene CAV1 and systemic sclerosis.