Note that many of theproteins that are upregulated in Cav-1 (-/-) stromal cells are alsotranscriptionally upregulated in the stroma of human breast cancer patients.Most notably, there was a strong association between the metabolic enzymes thatwere upregulated in Cav-1 (-/-) stromal cells and the "recurrence-prone" and"metastasis-prone" stromal gene lists. The gene discussed is CAV1; the disease is breast carcinoma.