After literature analysis, nine genes (ARID4A, CALR, GNB2L1, GPNMB, RNF10, SQSTM1, USP9X, PRDX1 and DAP3) showing potential involvement in signaling cascades related to tumorigenesis and/or stromal/tumor cell interactions were selected for validation by real-time RT-PCR using treated and non-treated cell lines. The gene discussed is GPNMB; the disease is neoplasm.