Preceded by several case reports [51,52], the first trial evidence that ACE inhibition may induce remission of nephrotic range proteinuria and stabilization of kidney function was provided by the Captopril Study, in which seven of 42 (16.7%) T1DM patients treated with captopril showed remission of nephrotic range proteinuria and stabilization of serum creatinine levels, compared with only one of 66 (1.5%) patients assigned to placebo [53]. Here, ACE is linked to Nephrotic range proteinuria.