A preliminary report from a randomized placebo-controlled clinical trial recently showed that 2 μg/day of paricalcitol added on to RAS inhibitor therapy decreased albuminuria by > 30% in a large cohort of patients with T2DM and overt nephropathy, whereas the smaller dose of 1 μg/day had a non-significant effect on urinary albumin excretion, similar to that of placebo [90]. The gene discussed is ALB; the disease is kidney disorder.