The absence of nephrotic syndrome is not necessarily linked with slight proteinuria and patients with normal serum albumin may have heavy proteinuria, this apparent paradox was earlier reported by Heptinstal.23 Hypertension is also variable in renal amyloidosis patients with reported incidence of 7–50%.15, 22 Nineteen out of forty three patients (44%) in the present series were hypertensive. The gene discussed is ALB; the disease is nephrotic syndrome.