Peripheral blood eosinophilia more than 1000 cells/μl, Type I and type III cutaneous reactivity to Aspergillus antigen, elevated serum titers of total IgE antibody, A. fumigatus specific IgE and IgG antibodies, and serum precipitin against A. fumigatus were positive in majority of patients, who underwent these tests. The gene discussed is IGHE; the disease is Increased total eosinophil count.