NFKB1 and cancer: Most surprisingly, although inhibition of NFκB activity in general contributes in chemosensitization of cancer cells [5,62], caspase activation is delayed and apoptosis is attenuated in K562/Adr cells treated with Siamois polyphenols, although efficacy of NFκB inhibition and initiation of early apoptosis by Siamois polyphenols is similar in doxorubicin-sensitive and resistant cell types.