NFKB1 and cancer: As anti-cancer properties of various polyphenols have been linked to inhibition of the inflammatory transcription factor NFκB, we first compared potential anti-inflammatory properties of the Siamois polyphenols quercetin, kaempferol, eriodictyol, WP283 and the withasteroid withaferin A (Fig. 1A) in NFκB-driven reporter gene assays.