Subjects comprised 11 type 2 diabetic patients (males: females, 9:2; mean age, 63.9 ± 7.8 years; mean BMI, 24.0 ± 4.0; mean duration of diabetes, 18.0 ± 12.0 years; mean U-CPR, 44.3 ± 37.8 μg/day; mean baseline HbA1c value, 8.4 ± 2.1%; and mean total daily insulin dose, 24.9 ± 8.9 units) (Table 1). The gene discussed is INS; the disease is diabetes mellitus.