CAV3 and inherited rippling muscle disease: The relevance of Cav-3 in muscle physiology was further confirmed by the findings that mutations in the CAV3 gene result in distinct neuromuscular and cardiac disorders, such as limb girdle muscular dystrophy (LGMD) 1-C, idiopathic persistent elevation of serum creatine kinase (hyperCKemia), inherited rippling muscle disease (RMD), distal myopathy and familial hypertrophic cardiomyopathy (HCM) [46-48].