MDM2 and well-differentiated liposarcoma: For this reason, studies have looked at the role of MDM2 in the pathogenesis of various tumors, including WDLS.[6] Detection of MDM2 amplification has been done by immunohistochemistry or by gene amplification studies (PCR, comparative genomic hybridization/CGH, FISH), and has been shown to be useful in distinguishing WDLS and dedifferentiated LPS from benign mimics.[7–10]