Notably, however, functional annotation of the differentially expressed genes (Supplemental Table S5) indicated the presence of a quasi-neoplastic molecular phenotype in the ovarian cystic epithelium, with up-regulation of oncogenic factors (e.g., EZH2, EVI1, MYB, ERBB4, CCNE1, MEIS1, KRAS2, MMP7, VEGF, MAPK1, MAPK9) and cancer-specific antigens (e.g., TACSTD1, WFDC2, CD44, CD24), and down-regulation of tumor suppressors (e.g., GADD45B, GAS1, PTEN, BAX). This evidence concerns the gene PTEN and cancer.