Taken together with the immunoblot results shown in Fig. 2, the IHC staining patterns obtained with monoclonal antibody 1E6 suggests that a 85–90 kDa palladin isoform is dramatically upregulated in the activated stromal fibroblasts of pancreatic adenocarcinoma tumors, and to a lesser degree in the stroma associated with fibrotic disease. This evidence concerns the gene PALLD and pancreatic adenocarcinoma.