Of note, based on previous work [17], he hypothesized that the transformation resulting from c-Myc and Klf4 was followed by a pluripotent cell induction process regulated by Pou5f1 and Sox2. Recently, the role of Trp53 in the generation of iPS cells strengthened this hypothesis and the emergence of cancer-like cells that act as an intermediate may be indispensable for getting pluripotent iPS cells successfully [18], [32], [33], [34], [35]. Here, POU5F1 is linked to cancer.