ADAMTS13 and hyperinsulinemic hypoglycemia, familial, 4: In the deficiency group, 27 patients received 2 infusions (4 cases), 3 infusions (2 cases), or 4 infusions (21 cases) of rituximab for refractory disease (8 cases), flare-up (11 cases), or chronic relapsing disease with persistent acquired severe ADAMTS13 deficiency (8 cases).