The clinical relevance of the Par-4-modulated genes with NFκB binding sites can be illustrated by our recurrent co-regulated network analysis of public microarray data derived from colon cancer patient specimens where 240 (including the microRNA pathway/regulation, pro-apoptotic and pro-survival genes) out of 687 genes were interconnected by 311 links (Figure 4A). This evidence concerns the gene NFKB1 and malignant colon neoplasm.