These findings together with results from previous studies on SOCS 2 expression in breast cancer [30,31], and the observations from another report confirming higher expression levels of SOCS3 in tissues from patients with lymph node negative breast cancer [32]; strongly suggest a highly significant negative correlation between SOCS proteins and advancing clinico-pathological stage and poorer differentiation of breast carcinoma. The gene discussed is CISH; the disease is breast carcinoma.