Although previous studies have demonstrated that NF-κB, STAT3 and/or PI3K play critical roles in growth control, survival, and chemotherapy resistance of B-cell and plasma-cell neoplasms [50-52], the precise function of NF-κB, STAT3 and/or PI3K in the development of these tumors is not completely understood. The gene discussed is PIK3CA; the disease is plasma cell neoplasm.