As mentioned initially, elevated inflammation markers were noticed in an adolescent with CRMO and acute presentation of inflammatory bowel disease (C-reactive protein, 13.9 mg/dl; ESR, 40 mm/hour; ferritin, 117 μg/l), and in patients with large numbers of radiological inflammatory bone lesions, especially with involvement of the spine or diaphyses of long bones. Here, CRP is linked to chronic recurrent multifocal osteomyelitis.