While integrin mediated adhesion to ECM components may contribute to the initiation of metastatic tumor cell arrest in organs with a discontinuous endothelium like the liver, in organs with a continuous endothelial lining like the lung, initial metastatic TC adhesion appears to be exclusively mediated by direct and/or indirect TC - EC interactions via glycosylated adhesion molecules, such as selectins and TF-antigens. This evidence concerns the gene TF and neoplasm.