GPT and diabetes mellitus: In indigenous system of medicines, Trichosanthes dioica (T. dioica, parwal or pointed gourd) is used to treat epilepsy, alopecia, skin disease and diabetes mellitus.[12] Rai et al. have reported that the LD50 of T. dioica is above 15 g/kg and the plant extract has shown significant reduction in liver enzymes (Alanine transaminase and Alkaline phosphatase) and serum creatinine.[13] The fruits and seeds of the plant have been reported to have hypoglycemic activity.[14, 15] The leaves of the plant are used in diabetes mellitus but there are no scientific studies on its hypoglycemic activity.