TNF and infection: Infection with Helicobacter pylori has been recognized as a public health problem worldwide[1] affecting approximately 50% of the world population and more prevalent in developing than the developed countries.[2] It is a common infection in diabetic patients who have inadequate metabolic control as such individuals are colonized by H. pylori infection in the gastric antrum, probably because of chemotactic factors such as tumor necrotic factor (TNF), interleukins-IL1, IL2, and IL8 are present in gastric epithelium.