FLT4 and neoplasm: In agreement, we found that VEGF-C/Flt-4 axis drove cervical cancer cell horizontal migration and three-dimensional invasion into matrices, which are consistent with limited reports that VEGF-C directly stimulated the motility of other types of cancer cells [10,30,31], confirming that in addition to the regulatory actions on lymphangiogenesis, VEGF-C can promote tumor cell metastasis by directly triggering cell migration and invasion in an autocrine fashion.