Previous reports indicated that TGFBR1*6A increased susceptibility of tumorigenesis and development in renal cell carcinoma, ovarian cancer, and breast cancer [12-14,16], although others found no association of TGFBR1*6A with the occurrence of lung cancer, prostate cancer, colon cancer and bladder cancer [17-21]. This evidence concerns the gene TGFBR1 and hereditary clear cell renal cell carcinoma.