Plasma endocannabinoid levels, which likely reflect to a large extent the "spill-over" of these lipid mediators from peripheral organs, are decreased postprandially or following oral glucose load and euglycaemic hyperinsulinaemic clamp in lean [3,8], but not in insulin resistant obese subjects [8], who, like T2D patients, show higher levels of endocannabinoids also when fasting [3-7,9]. Here, INS is linked to type 2 diabetes mellitus.