Our comparative proteomics data demonstrate that some components of mitochondrial complexes are significantly up-regulated in pituitary adenomas relative to controls; for example, ATP5B (ATP synthase, H+-transporting, mitochondrial F1 complex, beta polypeptide; 5-fold), COX6B1 (cytochrome c oxidase subunit Vib polypeptide 1; 9-fold), and NDUFS8 (NADH dehydrogenase ubiquinone Fe-S protein 8; 5-fold). This evidence concerns the gene NDUFS8 and pituitary gland adenoma.