Among those control pituitary adenoma qualitative nitroproteomic data, a total of 12 statistically significant canonical pathways were identified that involve nitroproteins (Figure 14), and include clatrin-mediated endocytosis, caveolar-mediated endocytosis, VEGF signaling, regulation of actin-based motility by Rho, Fcy receptor-mediated phagocytosis in macrophages and monocytes, tight-junction signaling, NRF2-mediated oxidative-stress response, leukocyte extravasation signaling, integrin signaling, actin-cytoskeleton signaling, and calcium signaling. The gene discussed is VEGFA; the disease is pituitary gland adenoma.