YWHAQ and pituitary gland adenoma: The 14-3-3 proteins (down-regulated 44-fold in pituitary adenomas compared to controls; Additional file 1, Table S2) are the important regulators in this pathway - they couple with Cdc25 B/C to participate in the nuclear export of Cdc25, and couple with Cdc2 and Cyclin B to participate in the cytoplasmic sequestration of cdc2 and cyclin B. The detailed components of the other canonical pathways that are derived from the pituitary adenoma nitroproteomic data are shown in Additional file 2, Figures S3.1-S3.10.