The most widely published among these, a synonymous coding PPARGC1A SNP rs2970847 (T394T), has been associated individually, in combination with other PPARGC1A SNPs in haplotype blocks, and in gene-gene interactions with relevant traits including diabetes risk, glucose uptake, obesity, and DNA damage in a variety of populations [47-54]. Here, PPARGC1A is linked to obesity due to melanocortin 4 receptor deficiency.