In line with previous studies of glioblastomas [24,27], these data indicates that the selective resistance of cells with stem-like properties (CD44high or rapid adhering cells) to apoptosis appears to be mediated through preferential activation of cell cycle checkpoints in response to DNA damage, and that these are reduced after inhibition of Chk1/Chk2 kinases. Here, CHEK2 is linked to glioblastoma.