6C). Similarly, higher expression of Pak1 was a significant unfavorable factor for disease-free survival (P < 0.0001, Figure. 6D). Although tumor grade, pT stage, LVI, active Rac1, and Pak1 were all significant factors by Cox univariate analysis, only LVI and Pak1 were independent variables according to multivariate analysis (Table 1). This evidence concerns the gene PAK1 and neoplasm.