HSPA1L and HSPA1A have been correlated with MS, diabetes and other immunity disorders, as well as regulatory functions such as chromatin remodelling, neuroprotection, protein folding, and regenerative-degenerative tools like neurodegeneration, neuron toxicity, cell survival, synaptic transmission and even aging factors (senescence and telomere maintenance). This evidence concerns the gene HSPA1A and diabetes mellitus.